CD20-Targeted Therapy Ablates De Novo Antibody Response to Vaccination but Spares Preestablished Immunity

T Shree, V Shankar, JJK Lohmeyer, DK Czerwinski… - Blood cancer …, 2022 - AACR
To obtain a deeper understanding of poor responses to COVID-19 vaccination in patients
with lymphoma, we assessed blocking antibodies, total anti-spike IgG, and spike-specific …

Immunological changes with kinase inhibitor therapy for chronic lymphocytic leukemia

C Pleyer, A Wiestner, C Sun - Leukemia & lymphoma, 2018 - Taylor & Francis
Ibrutinib and idelalisib are kinase inhibitors that have revolutionized the treatment of chronic
lymphocytic leukemia (CLL). Capable of inducing durable remissions, these agents also …

Can immunocompetence be restored in chronic lymphocytic leukemia?

C Sun, A Wiestner - Hematology/Oncology Clinics, 2021 - hemonc.theclinics.com
Immunodeficiency is a hallmark of chronic lymphocytic leukemia (CLL) and the cause of
much morbidity and mortality. As modern treatments increasingly provide long-term survival …

Anti-spike T-cell and antibody responses to SARS-CoV-2 mRNA vaccines in patients with hematologic malignancies

LM Greenberger, LA Saltzman, LM Gruenbaum… - Blood cancer …, 2022 - AACR
The anti-spike T-cell and antibody responses to SARS-CoV-2 mRNA vaccines in patients
with B-cell malignancies were examined in a real-world setting. A next-generation …

[HTML][HTML] Evolutionary clonal trajectories in nodular lymphocyte-predominant Hodgkin lymphoma with high risk of transformation

L Paschold, E Willscher, J Bein, M Vornanen… - …, 2021 - ncbi.nlm.nih.gov
The B-cell architecture of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is
complex since it is composed of malignant lymphocyte-predominant cells along with a rich B …

Case report: long-lasting SARS-CoV-2 infection with post-COVID-19 condition in two patients with chronic lymphocytic leukemia: the emerging therapeutic role of …

L Ballotta, O Simonetti, P D'Agaro, L Segat… - Frontiers in …, 2022 - frontiersin.org
Post-coronavirus disease 2019 (post-COVID-19) condition, previously referred to as long
COVID, includes a post-acute syndrome defined by the presence of non-specific symptoms …

Detection of disease-specific signatures in B cell repertoires of lymphomas using machine learning

P Schmidt-Barbo, G Kalweit, M Naouar… - PLOS Computational …, 2024 - journals.plos.org
The classification of B cell lymphomas—mainly based on light microscopy evaluation by a
pathologist—requires many years of training. Since the B cell receptor (BCR) of the …

A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells

A Brandt, J Matschke, W Fehrle… - Leukemia & …, 2019 - Taylor & Francis
Clonal bone marrow (BM) B-cell populations are a common finding in patients with
suspected primary central nervous system lymphoma (PCNSL). To assess their clinical …

[HTML][HTML] Deep sequencing of bone marrow microenvironments of patients with del (5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as …

T Mährle, N Akyüz, P Fuchs, N Bonzanni… - …, 2019 - ncbi.nlm.nih.gov
In myelodysplastic syndromes with a partial deletion of the long arm of chromosome 5, del
(5q), lenalidomide is believed to reverse anergic T-cell immunity in the bone marrow …

Successful treatment of acquired von Willebrand syndrome secondary to low-grade CLL with rituximab and venetoclax

A Boothby, L Hegerova, SN Fletcher… - Leukemia & …, 2024 - Taylor & Francis
Jill M. Johnsen c, d, e, fa university of Washington, Seattle, Wa, uSa; b Fred hutch Cancer
Center, university of Washington, Seattle, Wa, uSa; c Division of hematology and oncology …