Metal–organic frameworks (MOFs) are a class of important porous, crystalline materials
composed of metal ions (clusters) and organic ligands. Owing to the unique redox chemistry …

Free radicals, usually containing one or more unpaired electrons, are extremely unstable
and highly reactive with other biological molecules. Recently, there has been increasing …

Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing
treatment modality with the potential for deep-seated tumors without side effects on healthy …

In the recent years, ferroptosis, a novel non-apoptotic iron dependent form of programmed
cell death, gained lots of attention in the treatment of several disease like cancer, ischemic …

As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis,
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …

The therapeutic outcomes of oral nanomedicines against colon cancer are heavily
compromised by their lack of specific penetration into the internal tumor, favorable anti …

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to
conventional cancer treatment regimens. Its effective use as a cancer therapy requires a …

Increasing O2 demand and excessive ROS production are the main features of arthritic
microenvironment in rheumatoid arthritis (RA) joints and further play pivotal roles in …

Chemodynamic therapy (CDT) destroys cancer cells by converting H2O2 or O2 into reactive
oxygen species (ROS), but its therapeutic efficacy is restricted by the antioxidant capacity of …

Current antitumor monotherapy has many limitations, highlighting the need for novel
synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell …