Impairment of mitochondrial respiration in metabolic diseases: an overview

VF Avram, AP Merce, IM Hâncu, AD Bătrân… - International Journal of …, 2022 - mdpi.com
Mitochondrial dysfunction has emerged as a central pathomechanism in the setting of
obesity and diabetes mellitus, linking these intertwined pathologies that share insulin …

[HTML][HTML] Blood-based bioenergetics: a liquid biopsy of mitochondrial dysfunction in disease

MS Wilkinson, KJ Dunham-Snary - Trends in Endocrinology & Metabolism, 2023 - cell.com
Mitochondria operate as hubs of cellular metabolism that execute important regulatory
functions. Damaged/dysfunctional mitochondria are recognized as major pathogenic …

Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory study

T Lekva, AYFM Sundaram, MCP Roland, J Åsheim… - BMC medicine, 2023 - Springer
Abstract Background Circulating extracellular vesicles (EVs) are increased in preeclampsia
(PE) and are associated with severity and progression. We examined in this exploratory …

Placental oxidative stress and monoamine oxidase expression are increased in severe preeclampsia: A pilot study

AM Bînă, A Sturza, I Iancu, AG Mocanu… - Molecular and Cellular …, 2022 - Springer
Preeclampsia (PE) is the most severe complication of pregnancy with substantial burden of
morbidity and mortality for mother and neonate. The increased placental oxidative stress …

[HTML][HTML] Prognostic Utility of dNLR, ALRI, APRI, and SII in COVID-19 Patients with Diabetes: A Cross-Sectional Study

AI Danila, F Cioca, ST Gadde, SP Daruvuri, R Timar… - Diagnostics, 2024 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic has necessitated the identification of
biomarkers that can predict disease severity, particularly in vulnerable populations such as …

Dose-dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets

AM Beţiu, R Lighezan, VF Avram, DM Muntean… - Molecular and Cellular …, 2024 - Springer
Acetaminophen and ibuprofen are widely used over-the-counter medications to reduce
fever, pain, and inflammation. Although both drugs are safe in therapeutic concentrations …

Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study

DT Marti, F Bratosin, O Rosca, R Folescu, C Citu… - Antibiotics, 2024 - mdpi.com
This study investigates the complex interplay among genital infections, antibiotic usage, and
preterm birth. This study aims to identify common genital pathogens associated with preterm …

Risk Factors of Thrombophilia-Related Mutations for Early and Late Pregnancy Loss

E Borsi, O Potre, I Ionita, M Samfireag, C Secosan… - Medicina, 2024 - mdpi.com
Background and Objectives: This retrospective cohort study investigates the role of genetic
thrombophilia in pregnant women experiencing early pregnancy loss compared to those …

Molecular Markers in Melanoma Progression: A Study on the Expression of miRNA Gene Subtypes in Tumoral vs. Benign Nevi

M Prodan, S Costescu, A Elagez, SMD Laitin… - Current …, 2024 - mdpi.com
This study investigates the differential expression of miRNA gene subtypes in tumoral versus
benign nevi in individuals with melanoma, aiming to identify clinically significant correlations …

Comparing Relationship Satisfaction and Body-Image-Related Quality of Life in Pregnant Women with Planned and Unplanned Pregnancies

RI Daniluc, M Craina, BR Thakur, M Prodan, ML Bratu… - Diseases, 2024 - mdpi.com
This comparative cross-sectional study conducted at the “Pius Brinzeu” healthcare center in
Timisoara explored the differential impacts of pregnancy planning status on sexual function …