The piperazine scaffold is a privileged structure frequently found in biologically active
compounds. Piperazine nucleus is found in many marketed drugs in the realm of …

Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Amination of allylic alcohols is an effective approach in the facile synthesis of N-allylic
alkylation or N-alkylation amines. Recently, a series of catalysts were devised to push …

In this paper, we report the synthesis, and characterization of three piperazine based
multidentate ligands and their copper complexes. Ligands and complexes were …

A series of azole-containing piperazine derivatives have been designed and synthesized.
The obtained compounds were investigated in vitro for their antibacterial, antifungal and …

Copper-mediated trifluoromethylation of allylic chlorides and trifluoroacetates was
performed using a convenient Cu–CF3 reagent. The reaction is suitable for selective …

Secondary allylic alcohols were synthesized from linear allylic halides or carbonates using a
catalytic amount of a ruthenium complex in the presence of boronic acid. The effects of …

A series of novel Diallyl disulfide (DADS) derivatives were designed, synthesized and
evaluated as chemical agents, which target and modulate multiple facets of Alzheimer's …

Psychiatric disorders like schizophrenia and neurodegenerative diseases like Parkinson's
disease are associated with poly-factorial pathogenic mechanisms, with several …

Parkinson's Disease (PD) is a long-term neurodegenerative brain disorder that mainly
affects the motor system. The causes are still unknown, and even though currently there is …