The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Many proteins are translocated across the endoplasmic reticulum (ER) membrane in
eukaryotes or the plasma membrane in prokaryotes. These proteins use hydrophobic signal …

Hydrophobic signal sequences target secretory polypeptides to a protein-conducting
channel formed by a heterotrimeric membrane protein complex, the prokaryotic SecY or …

Many proteins are transported into the endoplasmic reticulum by the universally conserved
Sec61 channel. Post-translational transport requires two additional proteins, Sec62 and …

Membrane proteins are a highly relevant class of biological molecules and comprise∼ 60%
of current drug targets. Before being analyzed by structural, biochemical, and biophysical …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

Abstract The Sec61/SecY channel allows the translocation of many proteins across the
eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane. In …

In Escherichia coli, proteins found in the periplasm or the outer membrane are exported from
the cytoplasm by the general secretory, Sec, system before they acquire stably folded …

PpiD and YfgM are inner membrane proteins that are both composed of an N-terminal
transmembrane segment and a C-terminal periplasmic domain. Escherichia coli YfgM and …

The transport of proteins across or into membranes is a vital biological process, achieved in
every cell by the conserved Sec machinery. In bacteria, SecYEG combines with the SecA …