Diabetic Peripheral Neuropathy: Emerging Treatments of Neuropathic Pain and Novel Diagnostic Methods

J Røikjer, MK Borbjerg, T Andresen… - Journal of Diabetes …, 2024 - journals.sagepub.com
Background: Diabetic peripheral neuropathy (DPN) is a prevalent and debilitating
complication of diabetes, often leading to severe neuropathic pain. Although other diabetes …

Alterations in functional connectivity of thalamus and primary somatosensory cortex in painful and painless diabetic peripheral neuropathy

SS Croosu, J Røikjer, CD Mørch, N Ejskjaer… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE In this study we aimed to investigate the functional connectivity of brain regions
involved in sensory processing in diabetes with and without painful and painless diabetic …

[HTML][HTML] Neuropathic phenotypes of type 1 diabetes are related to different signatures of magnetic resonance spectroscopy-assessed brain metabolites

TM Hansen, SS Croosu, J Røikjer, CD Mørch… - Clinical …, 2024 - Elsevier
Objectives The study aimed to investigate brain metabolites in type 1 diabetes and the
associations with disease characteristics. We explored the metabolic profiles predicting …

[HTML][HTML] Quantification of white matter hyperintensities in type 1 diabetes and its relation to neuropathy and clinical characteristics

TM Hansen, SS Croosu, S Kianimehr, M Gjela… - Brain Research, 2025 - Elsevier
Aims The aims were to quantify periventricular and deep white matter hyperintensities
(WMHs) in adults with type 1 diabetes with different neuropathic phenotypes and to correlate …

Diagnostic accuracy of perception threshold tracking in the detection of small fiber damage in type 1 diabetes

J Røikjer, SS Croosu, BF Sejergaard… - Journal of Diabetes …, 2024 - journals.sagepub.com
Aim: An objective assessment of small nerve fibers is key to the early detection of diabetic
peripheral neuropathy (DPN). This study investigates the diagnostic accuracy of a novel …

Perception threshold tracking: validating a novel method for assessing function of large and small sensory nerve fibers in diabetic peripheral neuropathy with and …

J Røikjer, SS Croosu, JB Frøkjær, TM Hansen… - Pain, 2023 - journals.lww.com
It remains unknown why some people with diabetes develop painful neuropathies while
others experience no pain. This study aimed to validate a novel method for assessing the …

Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes

SS Croosu, M Gjela, J Røikjer… - Endocrinology …, 2023 - Wiley Online Library
Introduction Previous studies suggest that cognitive impairment is more prevalent in
individuals with painful and painless diabetic peripheral neuropathy (DPN). However, the …

The co-existence of sensory and autonomic neuropathy in type 1 diabetes with and without pain

J Røikjer, SS Croosu, TM Hansen, JB Frøkjær… - Acta Diabetologica, 2023 - Springer
Aims To investigate the co-existence of diabetic peripheral neuropathy (DPN), painful
diabetic peripheral neuropathy (PDPN), and cardiac autonomic neuropathy (CAN) and to …

[Retracted] A Retrospective Study on the Time in Range of Blood Glucose and Type 2 Diabetic Peripheral Neuropathy

M Li, K Wu, J Chang, W Jiang - BioMed Research International, 2022 - Wiley Online Library
Background. Time in range (TIR) is one of the basic indicators to assess glycemic control. In
this study, the TIR of DPN patients was used as the observation index to further evaluate the …

[HTML][HTML] Altered surface-based brain morphometry in type 1 diabetes and neuropathic pain

SNF Hostrup, SS Croosu, J Røikjer, CD Mørch… - Neuroscience, 2025 - Elsevier
This study explored surface brain morphometry in type 1 diabetes including focus on painful
diabetic peripheral neuropathy (DPN). Brain MRI was obtained from 56 individuals with …