Animal models of dengue virus infection

S Zompi, E Harris - Viruses, 2012 - mdpi.com
The development of animal models of dengue virus (DENV) infection and disease has been
challenging, as epidemic DENV does not naturally infect non-human species. Non-human …

Mouse models to study dengue virus immunology and pathogenesis

RM Zellweger, S Shresta - Frontiers in immunology, 2014 - frontiersin.org
The development of a compelling murine model of dengue virus (DENV) infection has been
challenging, because DENV clinical isolates do not readily replicate or cause pathology in …

Antibody recognition of cell surface-associated NS1 triggers Fc-γ receptor-mediated phagocytosis and clearance of West Nile virus-infected cells

KM Chung, BS Thompson, DH Fremont… - Journal of …, 2007 - Am Soc Microbiol
Previous studies have suggested that monoclonal antibodies (MAbs) to flavivirus
nonstructural protein-1 (NS-1) protect against infection in mice through an Fc-γ receptor …

Development of nucleic acid-based vaccines against dengue and other mosquito-borne flaviviruses: the past, present, and future

MB Bello, A Alsaadi, A Naeem, SA Almahboub… - Frontiers in …, 2025 - frontiersin.org
Due to their widespread geographic distribution and frequent outbreaks, mosquito-borne
flaviviruses, such as DENV (DENV), Zika virus (ZIKV), Japanese encephalitis virus (JEV) …

Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells

VD Krishna, M Rangappa… - Journal of virology, 2009 - Am Soc Microbiol
We demonstrate the presence of nonstructural protein 1 (NS1)-specific antibodies in a
significant proportion of convalescent-phase human serum samples obtained from a cohort …

Cross‐reaction, enhancement, and neutralization activity of dengue virus antibodies against zika virus: a study in the Mexican population

MR Montecillo-Aguado… - Journal of …, 2019 - Wiley Online Library
Zika virus (ZIKV), an emerging mosquito‐borne flavivirus, has quickly spread in many
regions around the world where dengue virus (DENV) is endemic. This represents a major …

Humanized mice in dengue research: a comparison with other mouse models

C Coronel-Ruiz, H Gutiérrez-Barbosa… - Vaccines, 2020 - mdpi.com
Dengue virus (DENV) is an arbovirus of the Flaviviridae family and is an enveloped virion
containing a positive sense single-stranded RNA genome. DENV causes dengue fever (DF) …

Can complementary prime-boost immunization strategies be an alternative and promising vaccine approach against dengue virus?

I Valdés, L Lazo, L Hermida, G Guillén… - Frontiers in Immunology, 2019 - frontiersin.org
Dengue is one of the most important diseases transmitted by mosquitoes. Dengvaxia®, a
vaccine registered in several countries, cannot be administered to non-immune individuals …

Long-term protection elicited by a DNA vaccine candidate expressing the prM-E antigen of dengue virus serotype 3 in mice

K Feng, X Zheng, R Wang, N Gao, D Fan… - Frontiers in Cellular …, 2020 - frontiersin.org
Dengue virus (DENV) is the causative agent of dengue, and its incidence has increased 30-
fold in the past five decades. Among the four cocirculating serotypes, DENV3 is associated …

Dengue Virus and Vaccines: How Can DNA Immunization Contribute to This Challenge?

AMB Alves, SM Costa, PBA Pinto - Frontiers in medical technology, 2021 - frontiersin.org
Dengue infections still have a tremendous impact on public health systems in most countries
in tropical and subtropical regions. The disease is systemic and dynamic with broad range of …