Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from
arachidonic acid, through the 5‐lipoxygenase (5‐LO) pathway. Owing to their properties …

Abstract Background Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are pro-inflammatory
mediators of the 5-lipooxygenase (5-LO) pathway, that play an important role in …

Glioblastoma is one of the most malignant and aggressive types of brain tumors. 5-
lipoxygenase and cysteinyl leukotriene receptor 1 (CysLT1) play a role in human …

Several drugs are effective in attenuating intestinal ischemia-reperfusion injury (IRI);
however little is known about the effect of montelukast. Fifty rats were randomly assigned to …

Introduction: Montelukast is recommended for the treatment of asthma, exercise-induced
bronchospasm and allergic rhinitis. Several trials demonstrated potential therapeutic effects …

Background: Inflammation, which is a hallmark of asthma, is one of the main sources of
oxidative stress in the human body. Thiols are powerful antioxidants that protect cells …

Background: There is ample knowledge reported in the literature about the role of oxidative
stress in asthma pathogenesis. It is also known that the interaction of reactive oxygen …

Cysteinyl leukotrienes (CysLTs) have been defined as central mediators of inflammation.
Despite our extensive understanding of these bioactive lipid mediators in the pathogenesis …

ABSTRACT BACKGROUND: Ischemia/reperfusion injury of the intestines is a severe
surgical condition. This study aimed to reveal ozone therapy effects with relatively increased …

Hepatic ischemia-reperfusion injury (IRI) occurs in a number of clinical conditions such as
trauma, hypovolemic shock, hepatic resection, and liver transplantation. Although several …