lncRNA CYTOR promotes aberrant glycolysis and mitochondrial respiration via HNRNPC-mediated ZEB1 stabilization in oral squamous cell carcinoma
W Zhu, J Wang, X Liu, Y Xu, R Zhai, J Zhang… - Cell death & …, 2022 - nature.com
Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral and
maxillofacial region, severely affects human health. However, current treatments for OSCC …
maxillofacial region, severely affects human health. However, current treatments for OSCC …
Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration
E Gavilán, R Medina-Guzman… - Cells, 2024 - mdpi.com
The COVID-19 pandemic has brought to the forefront the intricate relationship between
SARS-CoV-2 and its impact on neurological complications, including potential links to …
SARS-CoV-2 and its impact on neurological complications, including potential links to …
A viral biomolecular condensate coordinates assembly of progeny particles
Biomolecular condensates formed by phase separation can compartmentalize and regulate
cellular processes,. Emerging evidence has suggested that membraneless subcellular …
cellular processes,. Emerging evidence has suggested that membraneless subcellular …
RNA recognition by PKR during DNA virus infection
R Zhang, J Karijolich - Journal of Medical Virology, 2024 - Wiley Online Library
Protein kinase R (PKR) is a double‐stranded RNA (dsRNA) binding protein that plays a
crucial role in innate immunity during viral infection and can restrict both DNA and RNA …
crucial role in innate immunity during viral infection and can restrict both DNA and RNA …
Adenovirus E1B-55K controls SUMO-dependent degradation of antiviral cellular restriction factors
The human adenovirus species C type 5 (HAdV-C5) early region 1B 55 kDa (E1B-55K)
protein is a multifunctional protein that promotes viral replication and adenovirus-mediated …
protein is a multifunctional protein that promotes viral replication and adenovirus-mediated …
The Cajal body protein p80-coilin forms a complex with the adenovirus L4-22K protein and facilitates the nuclear export of adenovirus mRNA
Cajal bodies (CBs) are major sub-nuclear structures in most eucaryotic cells. In human
adenovirus 5 (Ad5) infection, CBs are reorganized into microfoci in the late phase of …
adenovirus 5 (Ad5) infection, CBs are reorganized into microfoci in the late phase of …
Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA
Eukaryotic cells recognize intracellular pathogens through pattern recognition receptors,
including sensors of aberrant nucleic acid structures. Sensors of double-stranded RNA …
including sensors of aberrant nucleic acid structures. Sensors of double-stranded RNA …
Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A
N Sun, J Zhang, C Zhang, T Xie, Z Zhang… - Journal of …, 2023 - Am Soc Microbiol
Human adenovirus (HAdV) is ubiquitous in the human population, constituting a significant
burden of global respiratory diseases. Children and individuals with low immunity are at risk …
burden of global respiratory diseases. Children and individuals with low immunity are at risk …
Identification of Adenovirus E1B-55K Interaction Partners through a Common Binding Motif
The adenovirus C5 E1B-55K protein is crucial for viral replication and is expressed early
during infection. It can interact with E4orf6 to form a complex that functions as a ubiquitin E3 …
during infection. It can interact with E4orf6 to form a complex that functions as a ubiquitin E3 …
E1B-55K is a phosphorylation-dependent transcriptional and posttranscriptional regulator of viral gene expression in human adenovirus C5 infection
The multifunctional adenoviral E1B-55K phosphoprotein is a major regulator of viral
replication and plays key roles in virus-mediated cell transformation. While much is known …
replication and plays key roles in virus-mediated cell transformation. While much is known …