The skin is the largest organ of the human body and the first line of defense against
environmental hazards. Many factors, including internal factors such as natural aging and …

Simple Summary Aging affects all cells of the body, leading to impaired system function.
Although scientists are beginning to identify some mechanisms underlying the aging …

Stem cells persist throughout the lifespan to repair and regenerate tissues due to their
unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in …

Ageing is a phenomenon in which cells, tissues and organs undergo systemic pathological
changes as individuals age, leading to the occurrence of ageing-related diseases and the …

Cellular senescence is a significant contributor to intervertebral disc aging and
degeneration. However, the application of senotherapies, such as senomorphics targeting …

Skin provides a physical and immune barrier to protect the body from foreign substances,
microbial invasion, and desiccation. Aging reduces the barrier function of skin and its rate of …

The skin, serving as the body's primary defense against external elements, plays a crucial
role in protecting the body from infections and injuries, as well as maintaining overall …

Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor
expressed in many tissues, including skin, where it is essential for maintaining skin barrier …

Chronic exposure to ultraviolet radiation (UVR) leads to premature aging of the skin, with
external manifestations of unsightly scars and internal molecular dysregulations that …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors involved in various physiological and pathological processes within the skin. PPARs …