Platelets are key vascular effectors in hemostasis, with activation signals leading to fast
recruitment, aggregation, and clot formation. The canonical process of hemostasis is well …

New findings unravel novel mechanotransduction pathways and effector functions in
platelets, establishing mechanobiology as a pivotal component of platelet function. These …

Platelets are key players in cardiovascular disease, and platelet aggregation represents a
central pharmacologic target, particularly in secondary prevention. However, inhibition of …

Neutrophils rapidly respond to inflammation and infection, but to which degree their
functional trajectories after mobilization from the bone marrow are shaped within the …

Shortening of airway smooth muscle and bronchoconstriction are pathognomonic for
asthma. Airway shortening occurs through calcium-dependent activation of myosin light …

Clot retraction results from retractions of platelet filopodia and fibrin fibers and requires the
functional platelet αIIbβ3 integrin. This assay is widely used to test the functions of platelets …

Background Although the prognosis of Philadelphia‐positive acute lymphoblastic leukemia
(Ph+ ALL) has improved with the introduction of tyrosine kinase inhibitors (TKIs) and stem …

Cyclic guanosine monophosphate (cGMP) is a second messenger produced by the NO-
sensitive guanylyl cyclase (NO-GC). The NO-GC/cGMP pathway in platelets has been …

Simple Summary The accumulation of senescent cells is now widely known to be a driver of
aging and many age-related pathologies, such as neurodegeneration and type 2 diabetes …

In this issue of Blood, Kaiser et al 1 pinpoint the glycoprotein IIb (GPIIB)/Gα13/Src tyrosine
kinase (c-Src)/14-3-3ζ signaling axis as a requirement for platelet migration and shed light …