Molnupiravir in COVID-19: A systematic review of literature

AK Singh, A Singh, R Singh, A Misra - Diabetes & Metabolic Syndrome …, 2021 - Elsevier
Background and aims Molnupiravir is a newer oral antiviral drug that has recently been
tested in COVID-19. We aim to conduct a systematic review of literature to find out the …

Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19

RT Eastman, JS Roth, KR Brimacombe… - ACS central …, 2020 - ACS Publications
The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven
the biomedical community to action—to uncover and develop antiviral interventions. One …

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

F Kabinger, C Stiller, J Schmitzová… - Nature structural & …, 2021 - nature.com
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the
treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA …

[HTML][HTML] Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

RM Cox, JD Wolf, RK Plemper - Nature microbiology, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is having a catastrophic
impact on human health 1. Widespread community transmission has triggered stringent …

β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells

S Zhou, CS Hill, S Sarkar, LV Tse… - The Journal of …, 2021 - academic.oup.com
Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized
to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses …

Novel coronavirus treatment with ribavirin: groundwork for an evaluation concerning COVID‐19

JS Khalili, H Zhu, NSA Mak, Y Yan… - Journal of medical …, 2020 - Wiley Online Library
Confronting the challenge of the outbreak of COVID‐19 should sharpen our focus on global
drug access as a key issue in antiviral therapy testing. The testing and adoption of effective …

Why are RNA virus mutation rates so damn high?

S Duffy - PLoS biology, 2018 - journals.plos.org
Why are RNA virus mutation rates so damn high? | PLOS Biology Skip to main content
Advertisement PLOS Biology Browse Current Issue Journal Archive Collections Find and …

The remarkable evolutionary plasticity of coronaviruses by mutation and recombination: insights for the COVID-19 pandemic and the future evolutionary paths of …

GD Amoutzias, M Nikolaidis, E Tryfonopoulou… - Viruses, 2022 - mdpi.com
Coronaviruses (CoVs) constitute a large and diverse subfamily of positive-sense single-
stranded RNA viruses. They are found in many mammals and birds and have great …

Colloquium: Criticality and dynamical scaling in living systems

MA Munoz - Reviews of Modern Physics, 2018 - APS
A celebrated and controversial hypothesis suggests that some biological systems—parts,
aspects, or groups of them—may extract important functional benefits from operating at the …

Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines

D Ruzek, TA Županc, J Borde, A Chrdle, L Eyer… - Antiviral Research, 2019 - Elsevier
Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV)
infection which is often limited to a febrile illness, but may lead to very aggressive …