Here, we review the'target-centric'genomic strategy to antimicrobial discovery and share our
perspective on identification, validation and prioritization of potential antimicrobial drug …

The serendipitous discovery of penicillin inspired intensive research into how small
molecules affect basic cellular processes and their potential to treat disease. Biochemical …

The explosion of sequence information in bacteria makes developing high-throughput, cost-
effective approaches to matching genes with phenotypes imperative. Using E. coli as proof …

The spread of antimicrobial resistance continues to be a priority health concern worldwide,
necessitating the exploration of alternative therapies. Cannabis sativa has long been known …

The molecular mechanisms of ethanol toxicity and tolerance in bacteria, although important
for biotechnology and bioenergy applications, remain incompletely understood. Genetic …

The outer membrane of Gram-negative bacteria is a formidable permeability barrier which
allows only a small subset of chemical matter to penetrate. This outer membrane barrier can …

Chemical-genetic approaches offer the potential for unbiased functional annotation of
chemical libraries. Mutations can alter the response of cells in the presence of a compound …

Antibiotic drug resistance among hospital and community acquired methicillin resistant
Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current therapeutics …

The low rate of discovery and rapid spread of resistant pathogens have made antibiotic
discovery a worldwide priority. In cell-based screening, the mechanism of action (MOA) is …

The dramatic rise in microbial drug resistance in recent years has led to ongoing searches
for novel drugs to add to the armory against infectious disease. Nevertheless, a paucity of …