Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …

This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

Brain swelling causes morbidity and mortality in various brain injuries and diseases but
lacks effective treatments. Brain swelling is linked to the influx of water into perivascular …

Recent advances in techniques to differentiate human induced pluripotent stem cells
(hiPSCs) hold the promise of an unlimited supply of human derived cardiac cells from both …

Sodium–calcium exchange (NCX) is the major calcium (Ca) efflux mechanism of ventricular
cardiomyocytes. Consequently the exchanger plays a critical role in the regulation of cellular …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

In the United States, sudden cardiac death accounts for an estimated 300,000 to 350,000
cases each year, with 80,000 presenting as the first manifestation of a preexisting …

Improved treatments for heart failure patients will require the development of novel
therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ …

Heart failure (HF) is characterized by molecular and cellular defects which jointly contribute
to decreased cardiac pump function. During the development of the initial cardiac damage …

Objectives: This study sought to identify electrocardiographic (ECG) criteria that are
associated with initiation of torsades de pointes (TdP) in patients with acquired (a-) and …