Human brain ontogeny is characterized by a considerably prolonged neotenic development
of cortical neurons and circuits. Neoteny is thought to be essential for the acquisition of …

Subcortical heterotopia is a cortical malformation associated with epilepsy, intellectual
disability, and an excessive number of cortical neurons in the white matter. Echinoderm …

Leveraging AAVs' versatile tropism and labeling capacity, we expanded the scale of in vivo
CRISPR screening with single-cell transcriptomic phenotyping across embryonic to adult …

Summary mRNA localization and local translation enable exquisite spatial and temporal
control of gene expression, particularly in polarized, elongated cells. These features are …

Alternative pre-mRNA splicing plays critical roles in brain development. SRSF10 is a
splicing factor highly expressed in central nervous system and plays important roles in …

Understanding the cellular and genetic mechanisms driving human-specific features of
cortical development remains a challenge. We generated a cell-type resolved atlas of …

Chromatin regulation plays a crucial role in neocortical neurogenesis, and mutations in
chromatin modifiers are linked to neurodevelopmental disorders. RBBP4 is a core subunit of …

Morphological development into evolutionary patterns under structural instability is
ubiquitous in living systems and often of vital importance for engineering structures. Here …

Neuronal migration is a highly dynamic process, and multiple cell movement metrics can be
extracted from time-lapse imaging datasets. However, these parameters alone are often …

During cortical development, both neurons and glial cells are generated in the germinal
zone near the lateral ventricle, migrate in the correct direction, and settle in their appropriate …