Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Membrane proteins are involved in numerous vital biological processes, including transport,
signal transduction and the enzymes in a variety of metabolic pathways. Integral membrane …

Almost 100 years after the discovery of the Raman scattering phenomenon, related
analytical techniques have emerged as important tools in biomedical sciences. Raman …

Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …

Cytochromes P450 (CYPs) represent a diverse group of heme-thiolate proteins found in
almost all organisms. CYPs share a common protein fold but differ in substrate selectivity …

Cytochrome P4503A4 (CYP3A4), a major human drug-metabolizing enzyme, is responsible
for the oxidation and clearance of the majority of administered drugs. One of the CYP3A4 …

The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often
under physiological conditions, catalyze many distinct oxidative transformations on a wide …

Although investigating drug modulation of cytochrome P450 (CYP) activity under
physiological conditions is crucial in drug development to avoid severe adverse drug …

Raman spectra of oxygenated intermediates of Nanodisc incorporated human CYP17 in the
presence of natural substrates directly confirm that substrate structure effectively alters H …

Abstract Triclosan (TCS), a broad-spectrum antibacterial chemical, has been extensively
used in personal daily care items, household commodities, and clinical medications; …