Current studies of vascular health, aging, and autophagy emphasize how the endothelium
adapts to stress and contributes to disease. The endothelium is far from an inert barrier to …

Myoblast fusion is an indispensable step for skeletal muscle development, postnatal growth,
and regeneration. Myeloid differentiation primary response gene 88 (MyD88) is an adaptor …

Objective The primary preclinical model of peripheral artery disease, which involves acute
limb ischemia (ALI), can result in appreciable muscle injury that is attributed to the acuity of …

Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, leads to
severe muscle wasting and eventual death of the afflicted individuals, primarily due to …

Peripheral artery disease (PAD) can result in limb loss within six months of diagnosis in a
subset of patients who cannot undergo endovascular or surgical revascularization yet …

Toll-like receptors (TLRs) play an important role in regulating muscle regeneration and
angiogenesis in response to ischemia. TLR2 knockout mice exhibit pronounced skeletal …

Gas gangrene, or clostridial myonecrosis, is usually caused by Clostridium perfringens and
may occur spontaneously in association with diabetes mellitus, peripheral vascular disease …

Skeletal muscle regeneration requires coordination between dynamic cellular populations
and tissue microenvironments. Macrophages, recruited via CCR2, are essential for …

Background We previously showed that the autophagy inhibitor chloroquine (CQ) increases
inflammatory cleaved caspase-1 activity in myocytes, and that caspase-1/11 is protective in …

Introduction Recent studies have demonstrated that adipose tissue-derived stem cell
(ADSC) transplantation could promote neoangiogenesis in various ischemic diseases …