The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Mass spectrometry (MS) has progressed to become a powerful analytical tool for both
quantitative and qualitative applications. The first mass spectrometer was constructed in …

A brief introduction is presented to the basic principles and application of a quadrupole–time‐
of‐flight (TOF) tandem mass spectrometer. The main features of reflecting TOF instruments …

The use of radio‐frequency (RF)‐only ion guides for efficient transport of ions through
regions of a mass spectrometer where the background gas pressure is relatively high is …

This paper reviews the literature published to September 2001 relating to the history, design,
operation and application of linear radio-frequency (rf)-driven multipole collision cells and …

We report the design and first applications of a tandem mass spectrometer (a quadrupole
time-of-flight mass spectrometer) optimized for the transmission and analysis of large …

Over the past decade, mass spectrometry has been revolutionized by access to instruments
of increasingly high mass-resolving power. For small molecules up to∼ 400 Da (eg, drugs …

Electrospray ionization mass spectrometry (ESI-MS) has demonstrated utility for the
detection and study of weakly bound, noncovalent complexes, including protein interactions …

How does the development of mass spectrometry (MS) for the study of protein complexes,
intact in the gas phase, contribute to the twin fields of genomics and proteomics? Foremost …