As warned by Sir Alexander Fleming in his Nobel Prize address:“the use of antimicrobials
can, and will, lead to resistance”. Antimicrobial resistance (AMR) has recently increased due …

Abstract Pharmacokinetic/pharmacodynamic (PK/PD) modelling is the initial step in the semi‐
mechanistic approach for optimizing dosage regimens for systemically acting antimicrobial …

Livestock manure is a major source of veterinary antibiotics and antibiotic resistance genes
(ARGs). Elucidation of the residual characteristics of ARGs in livestock manure following the …

Background An extensive exposure to antibiotics has been confirmed in children, but the
predictors and potential health risk remain unclear. Objective To investigate the predictors of …

Anaerobic digestion is one of the best ways to re-use animal manure and agricultural
residues, through the production of combustible biogas and digestate. However, the use of …

The binding of a drug to serum or plasma proteins enables the transport of drugs via the
blood to sites of action throughout the body. For expediency we will use serum proteins …

Danofloxacin and enrofloxacin are fluoroquinolones (FQs) used to treat and control bovine
respiratory disease (BRD) complex. While low toxicity, high bactericidal activity, and …

Enrofloxacin is a fluorquinolone exclusively developed for use in veterinary medicine
(1980). The kinetics of enrofloxacin are characterized, in general terms, by high …

We hypothesized that the residual concentrations of fluoroquinolones allowed in food
(acceptable daily intake—ADIs) could select for ciprofloxacin resistance in our resident …

Antimicrobials may reach the soil environment from a variety of sources and pathways,
including land application of human biosolids and animal manure. Once in soil …