Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities
are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation …

The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …

Motivation: Homology models of proteins are of great interest for planning and analysing
biological experiments when no experimental three-dimensional structures are available …

Spermatogenesis is a complex biological process of cellular transformation that produces
male haploid germ cells from diploid spermatogonial stem cells. This process has been …

Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian
heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle …

After a decade of extensive work on gene knockout mouse models of cell-cycle regulators,
the classical model of cell-cycle regulation was seriously challenged. Several unexpected …

A pharmacologic approach to male contraception remains a longstanding challenge in
medicine. Toward this objective, we explored the spermatogenic effects of a selective small …

Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …

Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent
kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a …

The piwi family genes, which are defined by conserved PAZ and Piwi domains, play
important roles in stem cell self-renewal, RNA silencing, and translational regulation in …