Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

Y Jiang, H Zhang, J Wang, Y Liu, T Luo… - Journal of hematology & …, 2022 - Springer
Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Extracellular matrix (ECM) stiffness and degradation as cancer drivers

M Najafi, B Farhood… - Journal of cellular …, 2019 - Wiley Online Library
Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis

H Zhou, M Wang, Y Zhang, Q Su, Z Xie… - Cancer …, 2022 - Wiley Online Library
Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

The curious case of vacuolar ATPase: regulation of signaling pathways

S Pamarthy, A Kulshrestha, GK Katara, KD Beaman - Molecular cancer, 2018 - Springer
Abstract The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the
intracellular and extracellular pH of cells. The structure of V-ATPase has been highly …

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

B Whitton, H Okamoto, G Packham… - Cancer medicine, 2018 - Wiley Online Library
Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …

Single-cell analysis reveals that cancer-associated fibroblasts stimulate oral squamous cell carcinoma invasion via the TGF-β/Smad pathway: Singel-cell sequencing …

W Yang, S Zhang, T Li, Z Zhou… - Acta biochimica et …, 2022 - pmc.ncbi.nlm.nih.gov
Although substantial progress has been made in cancer biology and treatment, the
prognosis of oral squamous cell carcinoma (OSCC) is still not satisfactory because of local …

[HTML][HTML] Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers

L Wang, GT Lang, MZ Xue, L Yang, L Chen, L Yao… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Triple-negative breast cancer (TNBC) is an aggressive malignancy with high
heterogeneity. However, the alternative polyadenylation (APA) profiles of TNBC remain …

Decellularization of tumours: A new frontier in tissue engineering

E García-Gareta, MÁ Pérez… - Journal of Tissue …, 2022 - journals.sagepub.com
Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix
(ECM) has unique features in terms of composition and mechanical properties, resulting in a …

Emerging insights on the role of V‐ATPase in human diseases: Therapeutic challenges and opportunities

C Santos‐Pereira, LR Rodrigues… - Medicinal Research …, 2021 - Wiley Online Library
The control of the intracellular pH is vital for the survival of all organisms. Membrane
transporters, both at the plasma and intracellular membranes, are key players in maintaining …

ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer

Y Li, F Li, X Bai, Y Li, C Ni, X Zhao, D Zhang - Frontiers in oncology, 2021 - frontiersin.org
Background ITGA3 is a member of the integrin family, a cell surface adhesion molecule that
can interact with extracellular matrix (ECM) proteins. The purpose of this study was to …