Small molecule, dietary antioxidants exert a remarkably broad range of bioactivities, and
many of these can be explained by the influence of antioxidants on the redox homeostasis …

N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical
transformation which provides routes for the synthesis of a wide range of pharmaceuticals …

An experimental approach is described for late-stage lead diversification of frontrunner drug
candidates using nanomole-scale amounts of lead compounds for structure–activity …

Chemicals often require metabolic activation to become genotoxic. Established test
guidelines recommend the use of the rat liver S9 fraction or microsomes to introduce …

A novel method for the selective catalytic N‐dealkylation of drug molecules on a nanoporous
gold (NPG) catalyst producing valuable N‐dealkylated metabolites and intermediates is …

The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive
(aminopropyl) groups enables efficient immobilization of synthetic metalloporphyrins (such …

Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising
way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5 …

The investigation of liver-related metabolic stability of a drug candidate is a widely used key
strategy in early-stage drug discovery. Metalloporphyrin-based biomimetic catalysts are …

In vitro mimicking of hepatic drug metabolism is a key issue in early-stage drug discovery.
Synthetic metalloporphyrins show structural similarity with the heme type prosthetic group of …

Biomimetic oxidation using synthetic iron‐porphyrin (F20TPPFeCl) as a catalyst eliminated a
xylene moiety of the fungicide mandestrobin, uniformly labeled with carbon‐14 at the benzyl …