From nuclear track characterization to machine learning based image classification in neutron autoradiography for boron neutron capture therapy

JS Viglietti, MS Espain, RF Díaz, LA Nieto, M Szewc… - Plos one, 2023 - journals.plos.org
Knowledge of the 10B microdistribution is of great relevance in BNCT studies. Since 10B
concentration assesment through neutron autoradiography depends on the correct …

Neutron autoradiography to study the microdistribution of boron in the lung

MS Espain, AMD Viegas, VA Trivillin… - Applied Radiation and …, 2020 - Elsevier
In Argentina, a multi-institutional project has been established to assess the feasibility of
applying BNCT ex-situ to the treatment of patients with multiple metastases in both lungs …

[HTML][HTML] Enhanced Resolution of Neutron Autoradiography with UV-C Sensitization to Study Boron Microdistribution in Animal Models

AM Portu, MS Espain, SI Thorp, VA Trivillin, P Curotto… - Life, 2023 - mdpi.com
The assessment of boron microdistribution is essential to evaluate the suitability of boron
neutron capture therapy (BNCT) in different biological models. In our laboratory, we have …

Neutron autoradiography with nuclear tracks detectors: an imaging technique for Boron Neutron Capture Therapy

AM Portu, MS Espain, JS Viglietti… - Journal of Physics …, 2023 - iopscience.iop.org
Abstract Boron Neutron Capture Therapy (BNCT) is a radiation treatment modality for cancer
based on the 10 B (n, α) 7 Li (BNC) reaction. Knowledge of the spatial location of boron …

Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications

A Ciardiello, S Altieri, F Ballarini, V Bocci, S Bortolussi… - Physica Medica, 2022 - Elsevier
Purpose One of the obstacles to the application of Boron Neutron Capture Therapy (BNCT)
and Proton Boron Fusion Therapy (PBFT) concerns the measurement of borated carriers' …

Measurement of an evaporation coefficient in tissue sections as a correction factor for 10B determination

N Espector, AM Portu, MS Espain, G Leyva… - Histochemistry and Cell …, 2023 - Springer
Boron neutron capture therapy (BNCT) is a cancer treatment option that combines
preferential uptake of a boron compound in tumors and irradiation with thermal neutrons. For …

Colocalization of tracks from boron neutron capture reactions and images of isolated cells

I Postuma, P Sommi, A Vitali, D Shu… - Applied Radiation and …, 2021 - Elsevier
Abstract In Boron Neutron Capture Therapy, the boronated drug plays a leading role in
delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic …

Optical density of high fluence autoradiographic images to study boron microdistribution: validation of the technique in tissue sections

MS Espain, JS Viglietti, C Vidal, D Martin… - Frontiers in Nuclear …, 2024 - frontiersin.org
The distribution of boron in biological samples coming from BNCT protocols can be
determined by the analysis of autoradiographic images formed by nuclear tracks on …

Extending neutron autoradiography technique for boron concentration measurements in hard tissues

L Provenzano, MS Olivera, G Saint Martin… - Applied Radiation and …, 2018 - Elsevier
The neutron autoradiography technique using polycarbonate nuclear track detectors (NTD)
has been extended to quantify the boron concentration in hard tissues, an application of …

Quantitative autoradiography in boron neutron capture therapy considering the particle ranges in the samples

S Takeno, H Tanaka, T Watanabe, T Mizowaki… - Physica Medica, 2021 - Elsevier
Purpose Boron neutron capture therapy is a cellular-scale particle therapy exploiting boron
neutron capture reactions in boron compounds distributed in tumour cells. Its therapeutic …