Hepatitis B virus research in South Africa

MB Maepa, A Ely, A Kramvis, K Bloom, K Naidoo… - Viruses, 2022 - mdpi.com
Despite being vaccine-preventable, hepatitis B virus (HBV) infection remains the seventh
leading cause of mortality in the world. In South Africa (SA), over 1.9 million people are …

Functional cure of hepatitis B virus infection in individuals with HIV-coinfection: a literature review

A Boyd, LNC Dezanet, K Lacombe - Viruses, 2021 - mdpi.com
In individuals infected with hepatitis B virus (HBV), the loss of hepatitis B surface antigen
(HBsAg) is the ultimate therapeutic goal, which defines “functional cure.” For individuals …

Long-term virological and serologic responses of chronic hepatitis B virus infection to tenofovir disoproxil fumarate-containing regimens in patients with HIV and …

YS Huang, HY Sun, SY Chang, YC Chuang… - Hepatology …, 2019 - Springer
Background Data regarding the durability of HBV viral suppression with combination
antiretroviral therapy (cART) containing tenofovir disoproxil fumarate (TDF) combined with …

HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa

TG Maponga, MI Andersson, CJ Van Rensburg… - BMC infectious …, 2018 - Springer
Background Co-infection with HIV negatively impacts the progression of chronic hepatitis B
virus (HBV) infection, including causing rapid progression to liver fibrosis. Sub-Saharan …

Hepatitis B serological markers and plasma DNA concentrations: baseline results from a treatment-monitoring practices trial

H Price, D Dunn, T Zachary, T Vudriko, M Chirara… - Aids, 2017 - journals.lww.com
Objectives: To examine hepatitis B (HBV) serological markers and plasma DNA
concentrations in a large group of untreated HBV/HIV-coinfected individuals in two sub …

Lamivudine monotherapy-based cART is efficacious for HBV treatment in HIV/HBV coinfection when baseline HBV DNA< 20,000 IU/mL

Y Li, J Xie, Y Han, H Wang, T Zhu, N Wang… - JAIDS Journal of …, 2016 - journals.lww.com
Background: Although combination antiretroviral therapy (cART) including tenofovir (TDF)+
lamivudine (3TC) or emtricitabine (FTC) is recommended for treatment of HIV/HBV …

Impact of lamivudine-based antiretroviral treatment on hepatitis B viremia in HIV-Coinfected south Africans

A Lukhwareni, MP Gededzha, E Amponsah-Dacosta… - Viruses, 2020 - mdpi.com
This prospective study investigated the impact of lamivudine-containing antiretroviral
therapy (ART) on HIV-positive patients in South Africa with baseline hepatitis B virus (HBV) …

High frequency of Lamivudine and Telbivudine resistance mutations in hepatitis B virus isolates from human immunodeficiency virus co-infected patients on highly …

H Bautista-Amorocho, JA Silva-Sayago… - Frontiers in …, 2023 - frontiersin.org
Hepatitis B virus (HBV) antiviral Resistance-Associated Mutations (RAMs) in human
immunodeficiency virus (HIV) coinfected patients undergoing highly active antiretroviral …

What does the scale‐up of long‐acting HIV pre‐exposure prophylaxis mean for the global hepatitis B epidemic?

AM Mohareb, MG Kouamé, M Nouaman… - Journal of the …, 2024 - Wiley Online Library
Introduction The HIV and hepatitis B virus (HBV) epidemics are interconnected with shared
routes of transmission and specific antiviral drugs that are effective against both viruses …

Hepatitis B virus (HBV) load response to 2 antiviral regimens, tenofovir/lamivudine and lamivudine, in HIV/HBV-coinfected pregnant women in Guangxi, China: the …

L Wang, J Wiener, M Bulterys, X Wei… - The Journal of …, 2016 - academic.oup.com
Background There is limited information on antiviral therapy for hepatitis B virus (HBV)
infection among pregnant women coinfected with human immunodeficiency virus (HIV) and …