Understanding the extracellular vesicle surface for clinical molecular biology

S Hallal, Á Tűzesi, GE Grau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐membrane enclosed nanoparticles that play significant
roles in health and disease. EVs are abundant in body fluids and carry an array of molecules …

Single-particle tracking for studying nanomaterial dynamics: applications and fundamentals in drug delivery

E Zagato, K Forier, T Martens, K Neyts… - …, 2014 - Taylor & Francis
Many macromolecular therapeutics could potentially treat genetic disorders and cancer.
They have, however, not yet reached the clinical stage owing to a lack of suitable carriers …

Probing the size limit for nanomedicine penetration into Burkholderia multivorans and Pseudomonas aeruginosa biofilms

K Forier, AS Messiaen, K Raemdonck, H Nelis… - Journal of Controlled …, 2014 - Elsevier
Encapsulation of antibiotics into nanoparticles is a potential strategy to eradicate biofilms. To
allow further optimization of nanomedicines for biofilm eradication, the influence of the …

The influence of movement on the localization precision of sub‐resolution particles in fluorescence microscopy

H Deschout, K Neyts, K Braeckmans - Journal of biophotonics, 2012 - Wiley Online Library
Obtaining sub‐resolution particle positions in fluorescence microscopy images is essential
for single particle tracking and high‐resolution localization microscopy. While the …

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

L De Backer, T Naessens, S De Koker, E Zagato… - Journal of Controlled …, 2015 - Elsevier
The local delivery of small interfering RNA (siRNA) to the lungs may provide a therapeutic
solution to a range of pulmonary disorders. Resident alveolar macrophages (rAM) in the …

In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier

B Naeye, H Deschout, V Caveliers, B Descamps… - Biomaterials, 2013 - Elsevier
Intravenous administration of siRNA nanocarriers may provide unique therapeutic
opportunities for tissue-specific gene silencing. Although often engineered to overcome the …

On-chip light sheet illumination enables diagnostic size and concentration measurements of membrane vesicles in biofluids

H Deschout, K Raemdonck, S Stremersch, P Maoddi… - Nanoscale, 2014 - pubs.rsc.org
Cell-derived membrane vesicles that are released in biofluids, like blood or saliva, are
emerging as potential non-invasive biomarkers for diseases, such as cancer. Techniques …

Intra-and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance

S Devos, S Stremersch, K Raemdonck… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
The treatment of Stenotrophomonas maltophilia infection with β-lactam antibiotics leads to
increased release of outer membrane vesicles (OMVs), which are packed with two …

Methods for measuring concentration (mass, surface area and number) of nanomaterials

S Palchoudhury, M Baalousha, JR Lead - Frontiers of Nanoscience, 2015 - Elsevier
Measuring the concentration of Nanomaterials (NMs) is a key to understanding NM fate,
behaviour, exposure and risk. This chapter discusses three most commonly measured …

Measuring the accessible surface area within the nanoparticle corona using molecular probe adsorption

M Park, DP Salem, D Parviz, X Gong, KS Silmore… - Nano …, 2019 - ACS Publications
The corona phase—the adsorbed layer of polymer, surfactant, or stabilizer molecules
around a nanoparticle—is typically utilized to disperse nanoparticles into a solution or solid …