Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …

Gynecological cancers are known for being very aggressive at their advanced stages.
Indeed, the survival rate of both ovarian and endometrial cancers is very low when …

The validation of prognostic biomarkers in large independent patient cohorts is a major
bottleneck in ovarian cancer research. We implemented an online tool to assess the …

BACKGROUND The objective of this study was to determine the clinical characteristics,
treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with …

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor
cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their …

Purpose: The p53 tumor suppressor gene plays a central role in cell cycle regulation and
induction of apoptosis. We analyzed p53 alterations and their impact on response to …

The most frequently expressed drug resistance genes, MDR1 and MRP1, occur in human
tumors with mutant p53. However, it was unknown if mutant p53 transcriptionally regulated …

YAP is a key component of the Hippo signaling pathway and plays a critical role in the
development and progression of multiple cancer types, including ovarian cancer. However …

Akt is a determinant of cisplatin [cis-diammine-dichloroplatinum (CDDP)] resistance in
ovarian cancer cells, and this may be related to the regulation of p53. Precisely how Akt …

The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …