Astrocytes are a heterogenous population of macroglial cells spread throughout the central
nervous system with diverse functions, expression signatures, and intricate morphologies …

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the
aging population and is characterized by a constellation of motor and non-motor symptoms …

The link between mitochondria and major depressive disorder (MDD) is increasingly
evident, underscored both by mitochondria's involvement in many mechanisms identified in …

Astrocytes express ionotropic receptors, including N-methyl-D-aspartate receptors
(NMDARs). However, the contribution of NMDARs to astrocyte-neuron interactions …

Dysregulation of mitochondrial calcium uptake mediated by the mitochondrial calcium
uniporter (MCU) is implicated in several pathophysiological conditions. Dinuclear ruthenium …

We report our investigation into the MCU-inhibitory activity of Co3+ complexes in
comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar …

Despite its devastating disease burden and alarming prevalence, the etiology of Parkinson's
disease (PD) remains to be completely elucidated. PD is characterized by the degeneration …

Astrocytes display a plethora of spontaneous Ca2+ signals that modulate vital functions of
the central nervous system (CNS). This suggests that astrocytic Ca2+ signals also contribute …

Astrocytes are one of the most numerous glial cells in the central nervous system (CNS) and
provide essential support to neurons to ensure CNS health and function. During a …

In multiple sclerosis (MS), glial cells astrocytes interact with the autoreactive immune cells
that attack the central nervous system (CNS), which causes and sustains neuroinflammation …