Soft‐tissue sarcomas (STS) are rare tumors that account for 1% of all adult malignancies,
with over 100 different histologic subtypes occurring predominately in the trunk, extremity …

Epigenetic regulation is critical to physiological control of development, cell fate, cell
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …

The ability to activate drugs only at desired locations avoiding systemic immunosuppression
and other dose limiting toxicities is highly desirable. Here we present a new approach …

Retroperitoneal liposarcoma (RLS) is a rare, biologically heterogeneous tumor that present
considerable challenges due to its size and deep location. As a consequence, the majority …

Gastrointestinal stromal tumor has received a lot of attention over the last 10 years due to its
unique biologic behavior, clinicopathological features, molecular mechanisms, and …

Leiomyosarcoma is one of the most frequent soft tissue sarcomas, with an estimated
incidence ranging between 10% and 20% of all newly diagnosed soft tissue sarcomas …

Background This expanded access program (EAP) was designed to provide trabectedin
access for patients with incurable soft tissue sarcoma (STS) following progression of disease …

Introduction The incidence and clinical significance of lymph node metastasis (LNM, N1) in
soft tissue sarcoma (STS) is unclear. Recent studies have focused on extremity/trunk STS …

Introduction The gastrointestinal stromal tumor (GIST) is the most common mesenchymal
tumor of the intestinal tract, known to be refractory to conventional chemotherapy or …

Primary treatment for many solid cancers includes surgical excision or radiation therapy,
with or without the use of adjuvant therapy. This can include the addition of radiation and …