The impact of systemic inflammation on Alzheimer's disease pathology

J Xie, L Van Hoecke, RE Vandenbroucke - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …

Cognitive aging and the promise of physical activity

KI Erickson, SD Donofry, KR Sewell… - Annual Review of …, 2022 - annualreviews.org
Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting
to emphasize the hope of preservation and enhancement of cognitive function in late life? A …

[HTML][HTML] Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

S Pugazhenthi, L Qin, PH Reddy - … acta (BBA)-molecular basis of disease, 2017 - Elsevier
Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most …

Neurological consequences of obesity

PD O'Brien, LM Hinder, BC Callaghan… - The Lancet …, 2017 - thelancet.com
The high prevalence of obesity is associated with an enormous medical, social, and
economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by …

Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies

K Deckers, MPJ van Boxtel… - … journal of geriatric …, 2015 - Wiley Online Library
Objective Dementia has a multifactorial etiology, but the importance of individual health and
lifestyle related risk factors is often uncertain or based on few studies. The goal of this paper …

The impact of free sugar on human health—a narrative review

KM Gillespie, E Kemps, MJ White, SE Bartlett - Nutrients, 2023 - mdpi.com
The importance of nutrition in human health has been understood for over a century.
However, debate is ongoing regarding the role of added and free sugars in physiological …

Metabolic syndrome as a risk factor for Alzheimer's disease: a focus on insulin resistance

A Ezkurdia, MJ Ramírez, M Solas - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the main type of dementia and is a disease with a profound
socioeconomic burden due to the lack of effective treatment. In addition to genetics and …

Obesity and cognitive decline: role of inflammation and vascular changes

JCD Nguyen, AS Killcross, TA Jenkins - Frontiers in neuroscience, 2014 - frontiersin.org
The incidence of obesity in middle age is increasing markedly, and in parallel the
prevalence of metabolic disorders including cardiovascular disease and type II diabetes is …

Environment and gene association with obesity and their impact on neurodegenerative and neurodevelopmental diseases

MT Flores-Dorantes, YE Díaz-López… - Frontiers in …, 2020 - frontiersin.org
Obesity is a multifactorial disease in which environmental conditions and several genes play
an important role in the development of this disease. Obesity is associated with …

Midlife overweight and obesity increase late-life dementia risk: a population-based twin study

WL Xu, AR Atti, M Gatz, NL Pedersen, B Johansson… - Neurology, 2011 - AAN Enterprises
Objective: The relation of overweight to dementia is controversial. We aimed to examine the
association of midlife overweight and obesity with dementia, Alzheimer disease (AD), and …