Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

A properly functioning adaptive immune system signifies the best features of life. It is diverse
beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad …

Dendritic cells (DCs) have the capacity to initiate immune responses, but it has been
postulated that they may also be involved in inducing peripheral tolerance. To examine the …

To identify endocytic receptors that allow dendritic cells (DCs) to capture and present
antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated …

In mouse, a subset of dendritic cells (DCs) known as CD8α+ DCs has emerged as an
important player in the regulation of T cell responses and a promising target in vaccination …

The prevention and treatment of prevalent infectious diseases and tumors should benefit
from improvements in the induction of antigen-specific T cell immunity. To assess the …

Secondary lymphoid organ chemokine (SLC) is expressed in high endothelial venules and
in T cell zones of spleen and lymph nodes (LNs) and strongly attracts naive T cells. In mice …

The mannose receptor family comprises four glycoproteins each of which is a type I
transmembrane receptor with an N-terminal cysteine-rich domain, a single fibronectin type II …

The mouse CD8α+ DC subset excels at cross-presentation of antigen, which can elicit
robust CTL responses. A receptor allowing specific antigen targeting to this subset and its …

The spontaneous mutant mouse strain, plt/plt, lacks the secondary lymphoid organ
chemokine (SLC)-ser gene and has disrupted trafficking of T cells and dendritic cells (DCs) …