Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

Loss of physiological microglial function may increase the propagation of
neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we …

Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

Despite loss of grey matter volume and emergence of distinct cognitive deficits in young
adults diagnosed with schizophrenia, current treatments for schizophrenia do not target …

Aging can cause morphological transformation in human microglia indicative of cell
senescence, termed microglial dystrophy. However, cellular senescence is characterized by …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by chronic
neuroinflammation with amyloid beta-protein deposition and hyperphosphorylated tau …

Human life expectancy has increased over the past few centuries, and the incidence of
dementia in the older population is also projected to continue to rise. Neurodegenerative …

Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's …