Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration

J Krücken, L Holden-Dye, J Keiser, RK Prichard… - PLoS …, 2021 - journals.plos.org
Current mass drug administration (MDA) programs for the treatment of human river
blindness (onchocerciasis) caused by the filarial worm Onchocerca volvulus rely on …

Nematode chromosomes

PM Carlton, RE Davis, S Ahmed - Genetics, 2022 - academic.oup.com
The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic
biology, including genetics, development, cell biology, and genomics. A major factor in the …

CaeNDR, the Caenorhabditis Natural Diversity Resource

TA Crombie, R McKeown, ND Moya… - Nucleic Acids …, 2024 - academic.oup.com
Studies of model organisms have provided important insights into how natural genetic
differences shape trait variation. These discoveries are driven by the growing availability of …

Hormesis induced by silver iodide, hydrocarbons, microplastics, pesticides, and pharmaceuticals: Implications for agroforestry ecosystems health

E Agathokleous, D Barceló, J Rinklebe, C Sonne… - Science of The Total …, 2022 - Elsevier
Increasing amounts of silver iodide (AgI) in the environment are expected because of the
recent massive expansion of weather modification programs. Concurrently …

High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasites

MA Elfawal, E Goetz, YM Kim, P Chen… - ACS Infectious …, 2024 - ACS Publications
Gastrointestinal nematodes (GINs) are among the most common parasites of humans,
livestock, and companion animals. GIN parasites infect 1–2 billion people worldwide …

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains

AO Shaver, J Wit, CM Dilks, TA Crombie, H Li… - PLoS …, 2023 - journals.plos.org
Treatment of parasitic nematode infections in humans and livestock relies on a limited
arsenal of anthelmintic drugs that have historically reduced parasite burdens. However …

The impact of species-wide gene expression variation on Caenorhabditis elegans complex traits

G Zhang, NM Roberto, D Lee, SR Hahnel… - Nature …, 2022 - nature.com
Phenotypic variation in organism-level traits has been studied in Caenorhabditis elegans
wild strains, but the impacts of differences in gene expression and the underlying regulatory …

[HTML][HTML] Benzimidazoles cause lethality by inhibiting the function of Caenorhabditis elegans neuronal beta-tubulin

SB Gibson, E Ness-Cohn, EC Andersen - International Journal for …, 2022 - Elsevier
Parasitic nematode infections cause an enormous global burden to both humans and
livestock. Resistance to the limited arsenal of anthelmintic drugs used to combat these …

easyXpress: An R package to analyze and visualize high-throughput C. elegans microscopy data generated using CellProfiler

J Nyaanga, TA Crombie, SJ Widmayer, EC Andersen - PLoS One, 2021 - journals.plos.org
High-throughput imaging techniques have become widespread in many fields of biology.
These powerful platforms generate large quantities of data that can be difficult to process …

Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections

V Banas, MA Elfawal, BA Rosa, M Mahoney… - ACS Infectious …, 2025 - ACS Publications
Soil-transmitted helminth (STH) infections affect one-fourth of the global population and
pose a significant threat to human and animal health, with limited treatment options and …