The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission
through the clearance of dopamine from the extracellular space. Dysregulation of DAT is …

Solute carrier transporters (SLCs) are a class of important transmembrane proteins that are
involved in the transportation of diverse solute ions and small molecules into cells. There are …

Depression is one of the most common mental illnesses, affecting almost 300 million people.
According to the WHO, depression is one of the world's leading causes of disability and …

Rationale Assessment of the bioeffect of serotonin reuptake inhibitors (SRIs, including both
selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake …

The high structural similarity, especially in transmembrane regions, of dopamine,
norepinephrine, and serotonin transporters, as well as the lack of all crystal structures of …

The rapidly evolving psychedelic industry has garnered considerable attention due to 3, 4-
methylenedioxymethamphetamine-assisted psychotherapy's ground-breaking success in …

BRD4 plays an indispensable role in cell cycle regulation, affecting processes such as cell
proliferation, apoptosis and transcription. In this article, a three‐dimensional quantitative …

Monoamine transporters (MATs) are targets of a wide range of compounds that have been
developed as therapeutic treatments for various neuropsychiatric and neurodegenerative …

In the past 20 years there have been great leaps in the understanding of the structure and
mechanism of monoamine transporters (MATs) owing to X-ray crystallography and cryo-EM …

The dopamine transporter (DAT) is a member of the neurotransmitter: sodium symporter
(NSS) family, mediating the sodium-driven reuptake of dopamine from the extracellular …