Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease

H Walgrave, S Balusu, S Snoeck, EV Eynden… - Cell Stem Cell, 2021 - cell.com
Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …

[HTML][HTML] Adult hippocampal neurogenesis and alzheimer's disease: novel application of mesenchymal stem cells and their role in hippocampal neurogenesis

M Noureddini… - International Journal of …, 2021 - ncbi.nlm.nih.gov
The neurogenesis can occur in two regions of the adult mammalian brain throughout the
lifespan: the subgranular zone of the hippocampal dentate gyrus, and the subventricular …

A dual-drug enhanced injectable hydrogel incorporated with neural stem cells for combination therapy in spinal cord injury

Z Qi, T Zhang, W Kong, C Fu, Y Chang, H Li… - Chemical Engineering …, 2022 - Elsevier
Neuronal loss and the formation of glial scars are major pathological events that hinder
axonal regrowth and neural regeneration after severe spinal cord injury (SCI). Therapeutic …

Neural stem cells in the adult olfactory bulb core generate mature neurons in vivo

Ç Defteralı, M Moreno-Estellés, C Crespo… - Stem Cells, 2021 - academic.oup.com
Although previous studies suggest that neural stem cells (NSCs) exist in the adult olfactory
bulb (OB), their location, identity, and capacity to generate mature neurons in vivo has been …

Long-term tracing of individual human neural cells using multiphoton microscopy and photoconvertible polymer capsules

IV Smirnov, VS Usatova… - Journal of the …, 2024 - royalsocietypublishing.org
The study of human neural cells, their behaviour and migration are important areas of
research in the biomedical field, particularly for potential therapeutic applications. The safety …

VCAM1 labels a subpopulation of neural stem cells in the adult hippocampus and contributes to spatial memory

DY Wang, AF Luo, QR Bai, XL Gong, Y Zheng, Q Shen… - Stem Cell Reports, 2020 - cell.com
Active neural stem cells (aNSCs) and quiescent neural stem cells (qNSCs) are two distinct
subpopulations found in the adult hippocampal dentate gyrus (DG). However, to date, no …

[HTML][HTML] Lentiviral vector-mediated transduction of adult neural stem/progenitor cells isolated from the temporal tissues of epileptic patients

S Abdolahi, A Khodakaram-Tafti, H Aligholi… - Iranian Journal of …, 2020 - ncbi.nlm.nih.gov
Objective (s): Neural stem/progenitor cells (NS/PCs) hold a great potential for delivery of
therapeutic agents into the injured regions of the brain. Efficient gene delivery using NS/PCs …

Impaired adult hippocampal neurogenesis in Alzheimer's disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement

E Salta, H Walgrave, S Balusu, E Vanden Eynden… - BioRxiv, 2020 - biorxiv.org
Adult hippocampal neurogenesis (AHN) plays a crucial role in memory processes and is
impeded in the brains of Alzheimer's disease (AD) patients. However, the molecular …

Nanotechnology in gene delivery for neural regenerative medicine

M Shahlaei, SM Asl, M Saeidifar - Neural Regenerative Nanomedicine, 2020 - Elsevier
Increased accumulation of transcribed protein from damaged DNA and the decreased ability
to repair DNA lead to many neurodegenerative diseases that lack effective therapies. Gene …

[PDF][PDF] A study on the cellular and molecular mechanisms underlying adult hippocampal neurogenic niche response to neuroinflammation

I Crisci - 2021 - iris.unito.it
The hippocampus is one of the most studied brain structures in rodents as a powerful model
for understanding its central role in learning, memory, spatial navigation, and behavioral …