The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively
spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are …

The transport of host proteins into and out of the nucleus is key to host function. However,
nuclear transport is restricted by nuclear pores that perforate the nuclear envelope. Protein …

A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …

Nuclear export complexes composed of rev response element (RRE) ribonucleic acid (RNA)
and multiple molecules of rev protein are promising targets for the development of …

Recent advances in the study of virus-cell interactions have improved our understanding of
how viruses that replicate their genomes in the nucleus (eg, retroviruses, hepadnaviruses …

During HIV infection, intron-containing viral mRNAs are exported from the cell nucleus to the
cytoplasm to complete the replication cycle. Cellular restrictions on the export of …

Overlapping coding regions balance selective forces between multiple genes. One possible
division of nucleotide sequence is that the predominant selective force on a particular …

HTLV-1 is an oncovirus causing ATL and other inflammatory diseases such as HAM/TSP
and HU in about 5% of infected individuals. It is also known that HTLV-1-infected cells …

HIV-1 Rev mediates the nuclear export of intron-containing viral RNA transcripts and is
essential for viral replication. Rev is imported into the nucleus by the host protein importin β …

Background: To complete its replication cycle, HIV-1 requires the nucleocytoplasmic export
of intron-containing viral mRNAs. This process is ordinarily restricted by the cell, but HIV …