Vitamin B12 (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained
principally from food of animal origin. Cobalamin becomes bioavailable through a series of …

Background/Objectives Nitrous oxide (N2O) is known to have abuse potential, although
debate regarding the toxic effects of such abuse continues. Our objective was to review the …

Nitrous oxide (N 2 O; laughing gas) is clinically used as a safe anesthetic (dentistry,
ambulance, childbirth) and appreciated for its anti-anxiety effect. Since five years …

Abstract Nitrous oxide (N 2 O), also known as “laughing gas,” is a colorless, nonirritating
gas. Clinically, it is widely used as an inhaled anesthetic, analgesic, and anxiolytic. In recent …

Background: Nitrous oxide (N2O) has been used in clinical and recreational settings for over
150 years. Through inactivation of the Vitamin B12 dependent enzyme, methionine …

Background Prevalence of nitrous oxide (N2O) use appears to be increasing in numerous
countries worldwide, and excessive use has been associated with physical and mental …

Recreational nitrous oxide (N2O) use is widespread, and complications associated with its
use are increasingly common. We sought to identify risk factors, clinical features and …

Background Whilst the dangers of 'legal highs' have been widely publicised in the media,
very few cases of the neurological syndrome associated with the inhalation of nitrous oxide …

Abstract Background Nitrous oxide (N 2 O) is a commonly used inhaled anesthetic in
outpatient dental procedures. However, the increasing recreational use of N 2 O may result …

Background: Since 2000, the prevalence of recreational nitrous oxide (N2O) use has
increased in the Western world. Although N2O is a relatively safe drug, the overall increase …