Genetic and epigenetic alterations have been under concentrated investigations for many
years in order to unearth the molecules regulating human cancer pathogenesis. However …

The latest advances in the sequencing methods in head and neck squamous cell carcinoma
(HNSCC) tissues have revolutionized our understanding of the disease by taking off the veil …

Despite an old history behind the identification of the leading role of c‐Myc in
leukemogenesis, the road to constructing a therapeutic perspective for this molecule in …

Radiotherapy has a central role in the treatment of head and neck squamous cell carcinoma
(HNSCC). Activation of the PI3K/AKT/mTOR pathway can decrease the efficiency of …

Despite considerable progress in treatment protocols, B‐lineage acute lymphoblastic
leukemia (B‐ALL) displays a poor prognosis in about 15–20% of pediatric cases and about …

Based on the frequent over-expression of c-Myc in hematologic malignancies and its crucial
role in the regulation of diverse oncogenic pathways involved in leukomogenesis, intense …

Introduction As a vital mechanism of survival, lymphopoiesis requires the collaboration of
different signaling molecules to orchestrate each step of cell development and maturation …

Introduction: Over the last few years, several new synthetic drugs, particularly Bruton's
tyrosine kinase (BTK), phosphatidylinositol 3-kinase (PI3K) and BCL-2 inhibitors have been …

Buparlisib is a highly efficient and selective PI3K inhibitor and a member of the 2, 6‑
dimorpholinopyrimidine‑derived family of compounds. It selectively inhibits four isomers of …

The correlation between the Phosphoinositide 3-kinase (PI3K) axis and crucial mechanisms
involved in the maintenance of the neoplastic nature of multiple myeloma (MM) has recently …