Flavin-based electron bifurcation, a new mechanism of biological energy coupling

W Buckel, RK Thauer - Chemical reviews, 2018 - ACS Publications
There are two types of electron bifurcation (EB), either quinone-or flavin-based
(QBEB/FBEB), that involve reduction of a quinone or flavin by a two-electron transfer and two …

Functional genomics reveals that Clostridium difficileSpo0A coordinates sporulation, virulence and metabolism

LJ Pettit, HP Browne, L Yu, WK Smits, RP Fagan… - BMC genomics, 2014 - Springer
Background Clostridium difficile is an anaerobic, Gram-positive bacterium that can reside as
a commensal within the intestinal microbiota of healthy individuals or cause life-threatening …

Hydrogen formation and its regulation in Ruminococcus albus: involvement of an electron-bifurcating [FeFe]-hydrogenase, of a non-electron-bifurcating [FeFe] …

Y Zheng, J Kahnt, IH Kwon, RI Mackie… - Journal of …, 2014 - Am Soc Microbiol
Ruminococcus albus 7 has played a key role in the development of the concept of
interspecies hydrogen transfer. The rumen bacterium ferments glucose to 1.3 acetate, 0.7 …

Studies on the mechanism of electron bifurcation catalyzed by electron transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) of Acidaminococcus …

NP Chowdhury, AM Mowafy, JK Demmer… - Journal of Biological …, 2014 - ASBMB
Electron bifurcation is a fundamental strategy of energy coupling originally discovered in the
Q-cycle of many organisms. Recently a flavin-based electron bifurcation has been detected …

Reduction of ferredoxin or oxygen by flavin‐based electron bifurcation in Megasphaera elsdenii

NP Chowdhury, J Kahnt, W Buckel - The FEBS Journal, 2015 - Wiley Online Library
Over 50 years ago, it was reported that, in the anaerobic rumen bacterium Megasphaera
elsdenii, the reduction of crotonyl‐CoA to butyryl‐CoA by NADH involved an electron …

Metabolic Engineering of Escherichia coli for Production of Butyric Acid

M Saini, ZW Wang, CJ Chiang… - Journal of Agricultural and …, 2014 - ACS Publications
The butyrate production by engineered Escherichia coli is afflicted by both low titer and low
selectivity (defined as the butyrate/acetate (B/A) ratio). To address this issue, a strategy for …

On the mechanism of electron bifurcation by electron transferring flavoprotein and butyryl-CoA dehydrogenase

NP Chowdhury - 2014 - archiv.ub.uni-marburg.de
Flavin-based electron bifurcation (FBEB), discovered in 2008, is a novel mode of energy
coupling in anaerobic bacteria and archaea. The complex of electron-transferring …