Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are currently available for the
management of type 2 diabetes mellitus. SGLT2i acts by inhibiting renal SGLT2, thereby …

Objectives The protective role of sodium glucose cotransporter 2 (SGLT2) inhibitors in renal
outcomes has been revealed by large cardiovascular outcome trials among patients with …

Background Chronic kidney disease (CKD) is a prevalent renal disorder with various risk
factors. Emerging evidence indicates that the transcriptional factor CCAAT/enhancer binding …

Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors have changed the
therapeutic landscape for diabetic kidney disease (DKD) patients, but their underlying …

Impaired fatty acid oxidation (FAO) is a metabolic hallmark of renal tubular epithelial cells
(RTECs) under diabetic conditions. Disturbed FAO may promote cellular oxidative stress …

Background/aims To investigate the specific effects of s odium-glucose transporter 2
inhibitor (SGLT2i) on cardiac energy metabolism. Methods A systematic literature search …

Autophagy is a protective mechanism through which cells degrade and recycle proteins and
organelles to maintain cellular homeostasis and integrity. An accumulating body of evidence …

Podocytes are particularly sensitive to lipid accumulation, which has recently emerged as a
crucial pathological process in the progression of proteinuric kidney diseases like diabetic …

Podocytes are the key target cells for injury across the spectrum of primary and secondary
proteinuric kidney disorders, which account for up to 90% of cases of kidney failure …