Direct and indirect consequences of meiotic recombination: implications for genome evolution
MT Webster, LD Hurst - Trends in genetics, 2012 - cell.com
There is considerable variation within eukaryotic genomes in the local rate of crossing over.
Why is this and what effect does it have on genome evolution? On the genome scale, it is …
Why is this and what effect does it have on genome evolution? On the genome scale, it is …
Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome
E Axelsson, MT Webster, A Ratnakumar… - Genome …, 2012 - genome.cshlp.org
Analysis of diverse eukaryotes has revealed that recombination events cluster in discrete
genomic locations known as hotspots. In humans, a zinc-finger protein, PRDM9, is believed …
genomic locations known as hotspots. In humans, a zinc-finger protein, PRDM9, is believed …
Genes with monoallelic expression contribute disproportionately to genetic diversity in humans
An unexpectedly large number of human autosomal genes are subject to monoallelic
expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic …
expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic …
Autosomal monoallelic expression: genetics of epigenetic diversity?
In mammals, relative expression of the two parental alleles of many genes is controlled by
one of three major epigenetic phenomena: X chromosome inactivation, imprinting, and …
one of three major epigenetic phenomena: X chromosome inactivation, imprinting, and …
Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee
Background Social hymenoptera, the honey bee (Apis mellifera) in particular, have ultra-
high crossover rates and a large degree of intra-genomic variation in crossover rates …
high crossover rates and a large degree of intra-genomic variation in crossover rates …
Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation
Background Gene order in eukaryotic genomes is not random, with genes with similar
expression profiles tending to cluster. In yeasts, the model taxon for gene order analysis …
expression profiles tending to cluster. In yeasts, the model taxon for gene order analysis …
Highly variable recombinational landscape modulates efficacy of natural selection in birds
Determining the rate of protein evolution and identifying the causes of its variation across the
genome are powerful ways to understand forces that are important for genome evolution. By …
genome are powerful ways to understand forces that are important for genome evolution. By …
Genomic signatures of germline gene expression
G McVicker, P Green - Genome research, 2010 - genome.cshlp.org
Transcribed regions in the human genome differ from adjacent intergenic regions in
transposable element density, crossover rates, and asymmetric substitution and sequence …
transposable element density, crossover rates, and asymmetric substitution and sequence …
The characterisation of three types of genes that overlie copy number variable regions
C Woodwark, A Bateman - PloS one, 2011 - journals.plos.org
Background Due to the increased accuracy of Copy Number Variable region (CNV) break
point mapping, it is now possible to say with a reasonable degree of confidence whether a …
point mapping, it is now possible to say with a reasonable degree of confidence whether a …
Unraveling patterns of site-to-site synonymous rates variation and associated gene properties of protein domains and families
S Dimitrieva, M Anisimova - PLoS One, 2014 - journals.plos.org
In protein-coding genes, synonymous mutations are often thought not to affect fitness and
therefore are not subject to natural selection. Yet increasingly, cases of non-neutral …
therefore are not subject to natural selection. Yet increasingly, cases of non-neutral …