The majority of in vitro studies assessing cancer treatments are performed in two-
dimensional (2D) monolayers and are subsequently validated in in vivo animal models …

The present review provides a comprehensive outlook toward the possibilities of developing
a functional in vitro liver tissue model on a paper platform. To this end, we first addressed the …

Complex 3D bioengineered tumour models provide the opportunity to better capture the
heterogeneity of patient tumours. Patient-derived organoids are emerging as a useful tool to …

Patient‐derived organoids (PDOs) are emerging as powerful models to capture the genetic
heterogeneity of human tumors. However, the self‐assembling nature of PDOs limits their …

Multilayered and stacked cellulose paper has emerged as a promising platform for
construction of three-dimensional (3D) cell culture because of its low cost, good …

Many potential chemotherapeutics fail to reach patients. One of the key reasons is that
compounds are tested during the drug discovery stage in two-dimensional (2D) cell cultures …

Hypoxia is a common feature in solid tumors. Clinical samples show a positive correlation
between the expression of the hypoxia-inducible factor HIF-1α and estrogen receptor alpha …

Paper-based scaffolds support the three-dimensional culture of mammalian cells in tissue-
like environments. These Tissue Papers, a name that highlights the use of materials …

Paper, with advantages of low-cost, easy fabrication and disposal, flexibility and
renewability, is a suitable substrate material for various applications. Functionalization and …

In this communication, a paper-based 3D cell culture device integrated with electrochemical
biosensor was applied to on-line monitoring of dopamine release from PC12 cell damage …