The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Many Gram‐negative and Gram‐positive bacteria recycle a significant proportion of the
peptidoglycan components of their cell walls during their growth and septation. In many …

The exponentially increasing number of protein and nucleic acid sequences provides
opportunities to discover novel enzymes, metabolic pathways, and metabolites/natural …

Abstract The Structure–Function Linkage Database (SFLD, http://sfld. rbvi. ucsf. edu/) is a
manually curated classification resource describing structure–function relationships for …

Insight regarding how diverse enzymatic functions and reactions have evolved from
ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and …

Advances in technological and bioinformatics approaches have led to the generation of a
plethora of human gut metagenomic datasets. Metabolomics has also provided substantial …

Millions of protein database entries are not assigned reliable functions, preventing the full
understanding of chemical diversity in living organisms. Here, we describe an integrated …

With the success of an expanding array of genome sequencing projects, the number of
known protein sequences has been increasing exponentially. However, the sequences on …

The rapidly expanding number of protein sequences found in public databases can improve
our understanding of how protein functions evolve. However, our current knowledge of …

The sequence and functional diversity of enzyme superfamilies have expanded through
billions of years of evolution from a common ancestor. Understanding how protein sequence …