Y chromosome (ChrY), the male-specific sex chromosome, has been considered as a
genetic wasteland. Aging-related mosaic loss of ChrY (LOY) has been known for more than …

The Danish Twin Registry (DTR) was established in the 1950s, when twins born from 1870
to 1910 were ascertained, and has since been extended to include twins from birth cohorts …

The existence of a sex gap in human health and longevity has been widely documented.
Autosomal DNA methylation differences between males and females have been reported …

Background Many human disease phenotypes manifest differently by sex, making the
development of methods for incorporating X and Y-chromosome data into analyses vital …

Biobank research may lead to an improved understanding of disease etiology and advance
personalized medicine. Denmark (population~ 5.9 million) provides a unique setting for …

Although DNA methylation variation of autosomal CpGs provides robust age predictive
biomarkers, no male-specific age predictor exists based on Y-CpGs yet. Since sex …

Sex differences in human survival have been extensively investigated in many studies that
have in part uncovered the biological determinants that promote a longer life in females with …

The Y chromosome is the most gene-deficient chromosome in the human genome (though
not the smallest chromosome) and has largely been sequestered away from large-scale …

Background DNA analysis for forensic investigations has a long tradition with important
developments and optimizations since its first application. Traditionally, short tandem …

Mosaicism in blood varies with age, and cross-sectional studies indicate that for women,
skewness of X-chromosomal mosaicism increases with age. This pattern could, however …