The impact of pharmacogenetic testing in patients exposed to polypharmacy: a scoping review

EL Meaddough, SM Sarasua, TK Fasolino… - The …, 2021 - nature.com
Polypharmacy poses a significant risk for adverse reactions. While there are clinical decision
support tools to assist clinicians in medication management, pharmacogenetic testing to …

Efficacy and Safety of Pitavastatin in Patients with Impaired Glucose Tolerance: An Updated Review

H Arsh, A Ali, RR Khenhrani, FNU Simran… - Current Problems in …, 2023 - Elsevier
This review provides an updated overview of the efficacy and safety of pitavastatin in
patients with impaired glucose tolerance (IGT). IGT is a prediabetic state characterized by …

Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment

L Fernandes Silva, R Ravi, J Vangipurapu, A Oravilahti… - Metabolites, 2022 - mdpi.com
Organic-anion-transporting polypeptide 1B1 (OATP1B1), encoded by the solute carrier
organic anion transporter family member 1B1 gene (SLCO1B1), is highly expressed in the …

[PDF][PDF] The lipid-lowering efficacy of rosuvastatin is associated with variations in SLCO1B1: a 12-month prospective cohort study.

M Zakria, A Hussain, N Ahmad… - European Review for …, 2023 - europeanreview.org
OBJECTIVE: Statins' efficacy and safety are subject to wide inter-individual variability, partly
due to genetic predisposition. Studies have shown that the genetic variations in the common …

Farmacogenômica e Doença Cardiovascular: Onde Estamos e Para Onde Vamos

R Stein, T Beuren, LR Cela, F Ferrari - Arquivos Brasileiros de …, 2020 - SciELO Brasil
A farmacogenômica (FGx) investiga a interação entre genes e medicamentos. Através da
análise de regiões específicas do DNA, informações sobre o perfil de metabolização do …

[HTML][HTML] Статин-ассоциированные мышечные поражения: возможные риски и потенциал фармакогенетического подхода к их предупреждению

АА Некрасов, ЛА Луговая, ТА Некрасова… - Атеросклероз и …, 2023 - cyberleninka.ru
Статины относятся к наиболее эффективным гиполипидемическим препаратам, но их
прием может быть связан с побочными эффектами, включая статин-ассоциированные …

Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

M Giriyappagoudar, B Vastrad, R Horakeri, C Vastrad - bioRxiv, 2022 - biorxiv.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19) has made a serious public
health threat globally. To discover key molecular changes in COVID-19 and its secondary …

Pharmacogenomics and Cardiovascular Disease: Where are We and Where do We go from Here?

R Stein, T Beuren, LR Cela, F Ferrari - Arquivos Brasileiros de …, 2020 - SciELO Brasil
Pharmacogenomics (PGx) studies the interaction between genes and drugs. By analysis of
specific regions of DNA, it is possible to obtain information on patient's metabolization profile …