KATs off: Biomedical insights from lysine acetyltransferase inhibitors
Lysine acetyltransferase (KAT) enzymes including the p300, MYST, and GCN5 families play
major roles in modulating the structure of chromatin and regulating transcription. Because of …
major roles in modulating the structure of chromatin and regulating transcription. Because of …
Factors and mechanisms that influence chromatin-mediated enhancer–promoter interactions and transcriptional regulation
S Ito, ND Das, T Umehara, H Koseki - Cancers, 2022 - mdpi.com
Simple Summary The physical interactions between enhancers and promoters create
chromatin conformations involved in gene regulation. In cancer cells, the chromatin …
chromatin conformations involved in gene regulation. In cancer cells, the chromatin …
Epigenetic mechanisms to propagate histone acetylation by p300/CBP
M Kikuchi, S Morita, M Wakamori, S Sato… - Nature …, 2023 - nature.com
Histone acetylation is important for the activation of gene transcription but little is known
about its direct read/write mechanisms. Here, we report cryogenic electron microscopy …
about its direct read/write mechanisms. Here, we report cryogenic electron microscopy …
Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription
In all eukaryotes, acetylation of histone lysine residues correlates with transcription
activation. Whether histone acetylation is a cause or consequence of transcription is …
activation. Whether histone acetylation is a cause or consequence of transcription is …
A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model
The enhancer-promoter looping model, in which enhancers activate their target genes via
physical contact, has long dominated the field of gene regulation. However, the ubiquity of …
physical contact, has long dominated the field of gene regulation. However, the ubiquity of …
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during ESC differentiation
RM Boileau, KX Chen, R Blelloch - BioRxiv, 2022 - biorxiv.org
Enhancers are essential in defining cell fates through the control of cell type specific gene
expression. Enhancer activation is a multi-step process involving chromatin remodelers and …
expression. Enhancer activation is a multi-step process involving chromatin remodelers and …
[图书][B] Regulation of enhancer dynamics by MLL3/4 in embryonic stem cells
R Boileau - 2023 - search.proquest.com
The acquisition of cell fate is dependent on gene regulatory networks that are regulated
spatiotemporally by cell type specific transcription factors (TFs). In binding to a class of cis …
spatiotemporally by cell type specific transcription factors (TFs). In binding to a class of cis …