Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Cellular immune responses in the pathophysiology of preeclampsia

D Miller, K Motomura, J Galaz… - Journal of Leukocyte …, 2022 - academic.oup.com
Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at
20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality …

Roles of human trophoblasts' pattern recognition receptors in host defense and pregnancy complications

K Motomura, M Hara, I Ito, H Morita… - Journal of Reproductive …, 2023 - Elsevier
The immune system in pregnancy is able to protect pregnant mothers and fetuses from
pathogenic microorganisms even while permitting the mother to tolerate the semi-allogenic …

Divergent regulation of decidual oxidative-stress response by NRF2 and KEAP1 in preeclampsia with and without fetal growth restriction

SB Mundal, JJ Rakner, GB Silva, LM Gierman… - International Journal of …, 2022 - mdpi.com
Utero-placental development in pregnancy depends on direct maternal–fetal interaction in
the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental …

Deciphering the immunological interactions: targeting preeclampsia with Hydroxychloroquine's biological mechanisms

M Gajić, B Schröder-Heurich… - Frontiers in …, 2024 - frontiersin.org
Preeclampsia (PE) is a complex pregnancy-related disorder characterized by hypertension,
followed by organ dysfunction and uteroplacental abnormalities. It remains a major cause of …

Comprehensive analysis of the expression and functions of pattern recognition receptors in differentiated cytotrophoblasts derived from term human placentas

K Motomura, H Morita, N Okada, A Matsuda… - The Journal of …, 2023 - journals.aai.org
Pregnant women are exposed to various microbes, some of which can harm the mother
and/or fetus and can lead to life-long morbidity and even death. The syncytiotrophoblast …

Modeling the Progression of Placental Transport from Early‐to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization

S Kouthouridis, A Sotra, Z Khan… - Advanced …, 2023 - Wiley Online Library
The early‐stage placental barrier is characterized by a lack of fetal circulation and by a thick
trophoblastic barrier, whereas the later‐stage placenta consists of vascularized chorionic …

Infection and disruption of placental multidrug resistance (MDR) transporters: Implications for fetal drug exposure

CBV Andrade, LVA Lopes, TM Ortiga-Carvalho… - Toxicology and Applied …, 2023 - Elsevier
Abstract P-glycoprotein (P-gp, encoded by the ABCB1 gene) and breast cancer resistance
protein (BCRP/ABCG2) are efflux multidrug resistance (MDR) transporters localized at the …

Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gestational diabetes mellitus

V Alur, V Raju, B Vastrad, A Tengli, C Vastrad… - Bioscience …, 2021 - portlandpress.com
Gestational diabetes mellitus (GDM) is the metabolic disorder that appears during
pregnancy. The current investigation aimed to identify central differentially expressed genes …

[HTML][HTML] Pregnancy outcomes and child development effects of SARS-CoV-2 infection (PROUDEST trial): Protocol for a multicenter, prospective cohort study

GM Fernandes, F Motta, LMP Sasaki… - JMIR research …, 2021 - researchprotocols.org
Background: A growing body of evidence suggests that SARS-COV-2 infection during
pregnancy may affect maternal-fetal outcomes and possibly result in implications for the long …