Most of oral targeted therapies are tyrosine kinase inhibitors (TKIs). Oral administration
generates a complex step in the pharmacokinetics (PK) of these drugs. Inter-individual PK …

Purpose In the past decade, there has been an increase in the development and use of oral
anti-cancer medications (OAMs), especially for breast cancer–the most prevalent cancer in …

Pyrimidine (imatinib, dasatinib, nilotinib and pazopanib), pyridine (sorafenib) and pyrrole
(sunitinib) tyrosine kinase inhibitors (TKIs) are multi-targeted TKIs with high activity towards …

Alpha-1-acid glycoprotein (AGP, also known as AAG or orosomucoid) is an important
plasma protein involved in the binding and transport of many drugs, especially basic …

Therapeutic drug monitoring (TDM) can be defined as the measurement of drug in biological
samples to individualise treatment by adapting drug dose to improve efficacy and/or reduce …

Background Imatinib has dramatically improved the prognosis of advanced gastrointestinal
stromal tumours (GISTs). Clinical trial data showed that patients with trough imatinib plasma …

The use of targeted oral anticancer medications (OAMs) is becoming increasingly prevalent
in cancer care. Approximately 25–30% of the oncology drug pipeline involves oral agents …

The treatment of many malignancies has been improved in recent years by the introduction
of molecular targeted therapies. These drugs interact preferentially with specific targets that …

Adherence to oral chemotherapy regimens maximizes their effectiveness and minimizes any
potential toxicities. Factors specifically related to the treatment, patient, and health care …

Therapeutic drug monitoring (TDM) for anticancer drug imatinib has been suggested as the
best way to improve the treatment response and minimize the risk of adverse reactions in …