The implementation of continuous pharmaceutical manufacturing requires advanced control
strategies rather than traditional end product testing or an operation within a small range of …

Current processes for the production of recombinant adeno-associated virus (rAAV) are
inadequate to meet the surging demand for rAAV-based gene therapies. This article reviews …

Continuous manufacturing (CM) sends materials directly and continuously to the next step of
a process, eliminating hold times and reducing processing times. The potential benefits of …

The pharmaceutical industry is continuously overcoming ways to reduce its development
times to market and bring new medicines to patients with the highest quality standards …

While continuous manufacturing (CM) of pharmaceutical solid-based drug products has
been shown to be advantageous for improving the product quality and process efficiency in …

Process models are a growing tool for pharmaceutical manufacturing process design and
control. The Industry 4.0 paradigm promises to increase the amount of data available to …

Powder feeding is one of the most critical processes in continuous manufacturing of powder-
related products. Predictions of final product attributes have overlooked possible changes of …

The integration of continuous unit operations imposes a challenge on the pharmaceutical
companies aspiring to achieve plant-wide continuous manufacturing due to the additional …

BACKGROUND The determination of the residence time distribution of an entire process or
process step in integrated continuous biomanufacturing is required for process …

Residence time distribution (RTD) has been widely applied across various fields of chemical
engineering, including pharmaceutical manufacturing, for applications such as material …