[HTML][HTML] ROCK inhibition in models of neurodegeneration and its potential for clinical translation

JC Koch, L Tatenhorst, AE Roser, KA Saal… - Pharmacology & …, 2018 - Elsevier
Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

Role of RhoA-ROCK signaling in Parkinson's disease

M Iyer, MD Subramaniam, D Venkatesan… - European journal of …, 2021 - Elsevier
Parkinson's disease (PD) is a complex and widespread neurodegenerative disease
characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the …

Rho GTPases in intellectual disability: from genetics to therapeutic opportunities

V Zamboni, R Jones, A Umbach, A Ammoni… - International Journal of …, 2018 - mdpi.com
Rho-class small GTPases are implicated in basic cellular processes at nearly all brain
developmental steps, from neurogenesis and migration to axon guidance and synaptic …

The sirtuin 2 inhibitor AK-7 leads to an antidepressant-like effect in mice via upregulation of CREB1, BDNF, and NTRK2 pathways

E Guclu, SY Inan, HC Vural - Molecular neurobiology, 2022 - Springer
Depression is one of the most important and serious health problems in developing
countries which affects millions of people. It is associated with the decrease of the quality of …

Fasudil promotes α-synuclein clearance in an AAV-mediated α-synuclein rat model of Parkinson's disease by autophagy activation

YJ Yang, LL Bu, C Shen, JJ Ge, SJ He… - Journal of …, 2020 - content.iospress.com
Background: Parkinson's disease (PD) is the second most common neurodegenerative
disorder, but the disease-modifying therapies focusing on the core pathological changes are …

Botulinum neurotoxin a injected ipsilaterally or contralaterally into the striatum in the rat 6-OHDA model of unilateral Parkinson's disease differently affects behavior

VA Antipova, C Holzmann, O Schmitt… - Frontiers in Behavioral …, 2017 - frontiersin.org
Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. The loss
of dopaminergic neurons in the substantia nigra leads to a disinhibition of cholinergic …

Pharmakologische rho-Kinasen-Inhibition im H4-Zelllinien-Modell des Morbus Parkinson

HL Walle - 2024 - ediss.uni-goettingen.de
2 in der Initiation einer Willkürbewegung, sowie die Verlangsamung in der
Bewegungsdurchführung. Definitionsgemäß handelt es sich beim M. Parkinson um ein …

Rho/Rho-Kinaz yolağının bağlamsal korku koşullanmadaki rolü

NS Köse - 2022 - dspace.trakya.edu.tr
Özet Rho-kinaz yolağı nörogenez ve sinaptik plastisitede oldukça önemli bir role sahiptir. Bu
çalışmada Rho-kinaz yolağının bağlamsal korku koşullanmanın edinim, konsolidasyon, geri …

Efeitos do pré e pós-tratamento com propionato de testosterona nas alterações motoras e neuroquímicas em ratos lesionados por 6-hidroxidopamina

JMM Bispo - 2021 - ri.ufs.br
RESUMO EFEITOS DO PRÉ E PÓS-TRATAMENTO COM PROPIONATO DE
TESTOSTERONA NAS ALTERAÇÕES MOTORAS E NEUROQUÍMICAS EM RATOS …

Quality control

P Jones, S Baron, P Jones, S Baron - Retailing, 1991 - Springer
Manufacturers and retailers take it for granted that the consumer values quality in goods and
services. The Swedish furniture retailer IKEA have perhaps the clearest message on quality …