Macrophages are pleiotropic cells that assume a variety of functions depending on their
tissue of residence and tissue state. They maintain homeostasis as well as coordinate …

Upon infection, mycobacteria, such as Mycobacterium tuberculosis (Mtb) and
nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering …

The bacteriostatic and bactericidal effects and the transcriptional response of
Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were …

Mycobacterium tuberculosis is an intracellular pathogen of macrophages and escapes the
macrophages' bactericidal effectors by interfering with phagosome-lysosome fusion. IFN-γ …

Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …

One-third of the global human population harbours Mycobacterium tuberculosis in dormant
form. This dormant or latent infection presents a major challenge for global efforts to …

IFN-γ is essential for control of Mycobacterium tuberculosis infection in vitro and in vivo.
However, the mechanisms by which IFN-γ controls infection remain only partially …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is globally
known as one of the most important human pathogens. Mtb is estimated to infect nearly one …

Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency
caused by inborn errors of the phagocyte nicotinamide adenine dinucleotide phosphate …

Lung granulomas develop upon Mycobacterium tuberculosis (Mtb) infection as a hallmark of
human tuberculosis (TB). They are structured aggregates consisting mainly of Mtb-infected …